There is no train connection with the airport.
Car and bus
The airport is along the highway E50 that goes west of Prague, the route to the center of the city is clearly indicated on signs. Several city buses leave the bus station to Prague, the most important are bus line 119 to the Dejvická metro station (metro line A) and the express line 100 to the Zlicín metro station (metro line B). Between midnight and 03:30, when the metro does not operate, there is a special night bus line 510 to Prague. A special Airport Express bus goes to the Holešovice metro station (metro line C). For all buses you must purchase an extra ‘half’ ticket for large baggage.
Car rental - Prague (Ruzyne) Airport
On the ground level of parking garage C you can find counters for car rental companies: Alimex CR, Alamo/National, Avis, Budget, CS-Czechocar, Dvorak, Europcar, Hertz and Sixt. You can also reserve a rental car in advance using the service EasyTerra provides, they compare the rates of several providers in a single quote.
Taxis are in front of the Arrivals Hall (tel: +420(0)2 2056 1788). Taxi drivers in Prague are notorious for asking high prices from tourists, a ride to the center of the city normally costs between CZK 500 and 700, make a clear agreement with the driver about the price before you get in!
You can also choose a mini bus from the company Cedaz (tel: +420(0)2 2491 9240), this goes every 30 minutes for Namesti Republiky and you only pay CZK 90.00.
Parking garage C is directly across from the terminal, a week of parking costs CZK 2,000 and two weeks costs CZK 2,500. Short-term parking is by Terminal North 1 (Parking A, first 15 minutes free, then CZK 100 per half hour) and by Terminal North 2 (Parking E, first hour CZK 80.00, then CZK 70.99 per hour).